INA/NTS Call for abstracts and presentations
International Neurotoxicology Association (INA)
Neurotoxicity Society (NTS)
Florianopolis, Brazil, May 20-24, 2017.
Call for abstracts and presentations at the 2017 joint INA/NTS meeting
Please send an abstract of your recent neurotoxicology research for presentation at the joint 2017 INA/NTS meeting in Florianopolis, Brazil.
The word limit is 400 words including title, authors, affiliations and funding citations (see example below). The abstracts will be evaluated by the INA/NTS program and local organizing committees. Indicate presentation preference of platform, poster or either.
The deadline is February 1, 2017.
Email the abstracts to Ed Levin at firstname.lastname@example.org.
For further information visit each society's webpage:
Neural mechanisms of octochemerol-induced behavioral alterations
Marie Curie, Charles Darwin, Rosalind Franklin and Alois Alzheimer
Department of Brain Health, All Science University, Any-city, Somewhereland
Exposure to octochemerol is of concern because it is widespread in the environment, it has actions at a variety of neural signaling pathways and it causes behavioral dysfunction after exposure. Previous research has shown that cognitive function is impacted by octochemerol exposure in animal models. In vitro studies have shown that the abc, lmn and xyz neural signaling systems are affected by octochemerol. The current study was conducted to determine which of these neural effects or combination of effects is most responsible for the behavioral impairment caused by octochemerol. Adult test subjects of the requat species (N=15/treatment) were exposed to octochemerol chronically via osmotic minipumps (sc) for four weeks (0, 1, 2, 4 and 8 mg/kg/day). They were tested for effects on locomotor activity in the Loco-meterä apparatus, anxiety in the fear of falling (FoF) test and learning in the operant light-on/respond-here task. Concurrent neural measurements were made with optoepiomic evaluation of five brain areas including the infundibulum, substantia innominata, nucleus ambiguous, inferior olive and pulvinar. Key markers of the abc, lmn and xyz signaling pathways were assessed because they have been shown in previous studies to be affected by octochemerol. In addition, def, hij and rst systems were evaluated as they are important for the behaviors under study. Analysis of variance with Dunnett’s comparisons of treated groups to control and Bonferonni correction for multiple comparisons were used with p<0.05 as the threshold for significance. Octochemerol at the 8 mg/kg/day dose significantly impaired learning without significant effects on the locomotor activity or anxiety tests. The learning impairment was correlated with deficits in lmn activity, whereas octochemerol effects on abc and xyz were not found to be related to the learning impairment. A follow-up experiment with boostupitrol, an lmn agonist, reversed the octochemerol-induced learning impairment. Interestingly, we also found that reaction of the rst signaling system also played a role in the behavioral effects of octochemerol, even though this system is not directly affected by octochemerol in cell-based systems. Reaction of rst signaling may determine subgroup differential sensitivity to octochemerol neurobehavioral impairment. Further research is needed to determine the complex mechanistic interactions underlying octochemerol neurobehavioral toxicity.
This research was supported by the World Health Organization and the Nobel Prize Committee.